The Virus Identification Laboratory provides rapid-turnaround
diagnostic virology for a large number of viruses of clinical
importance. The full range of tests provided can be found in the
VIDRL
Test Handbook.
Virus detection is mainly carried out using polymerase chain reaction
(PCR)-based assays, several of which are multiplexed (Druce
2002). For example, the herpesvirus multiplex assay is able
to simultaneously detect HSV-1, HSV-2, CMV and VZV. The respiratory
virus PCR detects influenza viruses (types A and B), RSV, parainfluenza
viruses (types 1, 2 and 3), adenoviruses, rhinoviruses and enteroviruses.
All PCR assays used in the laboratory have undergone extensive
validation and incorporate internal controls to detect inhibitors
of PCR amplification. A charge is made for most of the PCR assays
provided by the laboratory.
Other activities undertaken in the Virus Identification Laboratory
involve those associated with its state, national or WHO related
responsibilities. Scientists in the laboratory are directly involved
in the running of the National High Security Quarantine Laboratory
and the WHO Measles Reference Laboratory.
The laboratory also has the designation of a National Influenza
Centre within the WHO Global Influenza Program.
As well as its diagnostic function, the Virus Identification Laboratory
has an ongoing research and development program. The program covers
- the study of mechanisms of drug resistance acquired by HSV
- the changing epidemiology of genital HSV infection
- molecular characterisation of human coronaviruses
- investigations of the stability of viruses under physical
and chemical conditions
